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doi: 10.1038/nrm3311 105 MorrisonSFMaddenCJTuponeD

Regular aerobic and resistance exercise preserves lean muscle, promotes fat loss, and improves insulin sensitivity

Nalbandian A et al

Cost and accessibility: Generic Metformin is widely available and significantly less expensive

Functional assessment may require mitochondrial respiration, proton-leak measurements, tissue temperature, oxygen consumption, adrenergic responsiveness, cold challenge, or whole-body energy-expenditure measurements